An NMD-type pathway linking the polyA tail and mRNA degradation
Gwenael Badis-Bréard, Institut Pasteur/CNRS UMR3525
The Nonsense-mediated mRNA decay (NMD) is the major surveillance pathway that degrades aberrant mRNAs with premature termination codons. We identified a population of deadenylated RNA molecules, distinct from NMD targets, that are specifically bound by the NMD core factor Upf1. How these RNA are generated and specifically bound by Upf1 is unknown. By analogy with the recruitment of Upf1 in NMD, we propose a mechanism leading to the recruitment of this helicase on non-canonical NMD targets.