Publications du LBMCE


Quinet G, Génin P, Ozturk O, Belgareh-Touzé N, Courtot L, Legouis R, Weil R, Cohen MM, Rodriguez MS. Exploring selective autophagy events in multiple biologic models using LC3-interacting regions (LIR)-based molecular traps. Sci Rep. 2022 May 10;12(1):7652. doi: 10.1038/s41598-022-11417-z. PMID: 35538106


Klionsky DJ, ……Belgareh-Touzé N, ………Cohen MM, ………Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751

H. Coutelier, O. Ilioaia, J. Le Peillet, M. Hamon, D. Amours, M. T. Teixeira and Z. Xu (2021). bioRxiv: 2021.2010.2020.465143. The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction.

H. Martin, M. Doumic, M. T. Teixeira and Z. Xu Cell Biosci (2021).Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae 

Martin H, Doumic M, Teixeira MT, Xu Z. (2021) Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae. bioRxiv : 2021.06.16.448683

Henninger EE, Jolivet P, Fallet E, Benmounah M, Xu Z, Mattarocci S, Teixeira MT (2020) Maturation of telomere 3’-overhangs is linked to the replication stress response. bioRxiv: 2020.2008.2027.269621


Henninger E, Teixeira MT (2020) Telomere-driven mutational processes in yeast. Curr Opin Genet Dev 60: 99-106

Alsayyah C, Ozturk O, Cavellini L, Belgareh-Touzé N, Cohen MM. The regulation of mitochondrial homeostasis by the Ubiquitin Proteasome System. Biochim Biophys Acta Bioenerg. 2020 Aug 27:148302. doi: 10.1016/j.bbabio.2020.148302.

Navickas A, Chamois S, Saint-Fort R, Henri J, Torchet C, Benard L (2020) No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1. Nature communications 11: 122.


Gilet J, Conte R, Torchet C, Benard L, Lafontaine I (2019) Additional layer of regulation via convergent gene orientation in yeasts. Molecular biology and evolution.

Brandner A, De Vecchis D, Baaden M, Cohen MM, Taly A. Structural dataset from microsecond-long simulations of yeast mitofusin Fzo1 in the context of membrane docking. Data in Brief 26, 104460

De Vecchis D, Brandner A, Baaden M, Cohen MM, Taly A. A Molecular Perspective on Mitochondrial Membrane Fusion: From the Key Players to Oligomerization and Tethering of Mitofusin. The Journal of membrane biology, 1-14

Brandner A, De Vecchis D, Baaden M, Cohen MM, Taly A. Physics-based oligomeric models of the yeast mitofusin Fzo1 at the molecular scale in the context of membrane docking. Mitochondrion. 2019 Jul 12. pii: S1567-7249(19)30051-0.

Findinier J, Delevoye C, Cohen MM. The dynamin-like protein Fzl promotes thylakoid fusion and resistance to light stress in Chlamydomonas reinhardtii. PLoS Genet. 2019 Mar 15;15(3):e1008047.

De Carpentier F, Lemaire SD, Danon A. When unity is strength: the strategies used by Chlamydomonas to survive environmental stresses. Cells, 8(11), 1307

Zaffagnini M, Fermani S, Marchand CH, Costa A, Sparla F, Rouhier N, Geigenberger P, Lemaire SD, Trost P (2019) Redox homeostasis in photosynthetic organisms: novel and established thiol-based molecular mechanisms. Antioxid Redox Signal. 31(3): 155-210

Vavitsas K, Crozet P, Hamborg Vinde M, Davies F, Lemaire SD, Vickers CE (2019) The synthetic biology toolkit for photosynthetic microorganisms. Plant Physiol. 181: 14-27.

Shao Z, Borde C, Marchand CH, Lemaire SD, Busson P, Gozlan JM, Escargueil A, Maréchal V (2019) Detection of IgG directed against a recombinant form of Epstein-Barr virus BALF0/1 protein in patients with nasopharyngeal carcinoma. Protein Expr. Purif. 162:44-50

Eberhard S, Valuchova S, Ravat J, Fulneček J, Jolivet P, Bujaldon S, Lemaire SD, Wollman FA, Teixeira MT, Riha K, Xu Z. (2019). Molecular characterization of Chlamydomonas reinhardtii telomeres and telomerase mutants. Life Sci Alliance. Jun 3;2(3).

De Mia M, Lemaire SD, Choquet Y, Wollman FA (2019) Nitric oxide remodels the photosynthetic apparatus under sulfur starvation in Chlamydomonas reinhardtii Plant Physiol. 179: 718-731 [Supp]

Marchand CH, Fermani S, Rossi J, Gurrieri L, Tedesco D, Henri J, Sparla F, Trost P, Lemaire SD, Zaffagnini M. (2019) Structural and biochemical insights into the reactivity of thioredoxin h1 from Chlamydomonas reinhardtii. Antioxidants 8, E10.

Xu Z. and Teixeira M.T. (2019). The many types of heterogeneity in replicative senescence. Yeast. Jul 15. doi: 10.1002/yea.3433. [Epub ahead of print]

Eberhard S, Valuchova S, Ravat J, Fulneček J, Jolivet P, Bujaldon S, Lemaire SD, Wollman FA, Teixeira MT, Riha K, Xu Z. (2019). Molecular characterization of Chlamydomonas reinhardtii telomeres and telomerase mutants. Life Sci Alliance. Jun 3;2(3). pii: e201900315. doi: 10.26508/lsa.201900315

Jolivet, P., Serhal, K., Graf, A., Eberhard, S., Xu, Z., Luke, B., and Teixeira, M.T. (2019). A subtelomeric region affects telomerase-negative replicative senescence in Saccharomyces cerevisiae. Scientific Reports 9(1): 1845

Coutelier, H., and Xu, Z. (2019). Adaptation in replicative senescence: a risky business. Curr Genet


Albertas Navickas, Sébastien Chamois, Rénette Saint-Fort, Julien Henri, Claire Torchet, Lionel Benard (2018) A unique No-Go Decay cleavage in mRNA exit-tunnel of ribosome produces 5’-OH ends phosphorylated by Rlg1. Pre-print in BioRxiv

Cohen MM. and Tareste D. Recent insights into the structure and function of Mitofusins in mitochondrial fusion. (2018) . F1000 Research. 7 (F1000 Faculty Rev):1983.

Shai N, Yifrach E, van Roermund CWT, Cohen N, Bibi C, IJlst L, Cavellini L, Meurisse J, Schuster R, Zada L, Mari MC, Reggiori FM, Hughes AL, Escobar-Henriques M, Cohen MM, Waterham HR, Wanders RJA, Schuldiner M, Zalckvar E. Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact. Nat Commun. 2018 May 2;9(1):1761.

Lemaire SD, Tedesco D, Crozet P, Michelet L, Fermani S, Zaffagnini M, Henri J (2018) Crystal Structure of Chloroplastic Thioredoxin f2 from Chlamydomonas reinhardtii Reveals Distinct Surface Properties. Antioxidants 7, E171.

Crozet P, Navarro FJ, Willmund F, Mehrshahi P, Bakowski K, Lauersen KJ, Pérez-Pérez M-E, Auroy P, Gorchs Rovira A, Sauret-Gueto S, Niemeyer J, Spaniol B, Theis J, Trösch R, Westrich L-D, Vavitsas K, Baier T, Hübner W, de Carpentier F, Cassarini M, Danon A, Henri J, Marchand CH, de Mia M, Sarkissian K, Baulcombe DC, Peltier G, Crespo J-L, Kruse O, Jensen P-E, Schroda M, Smith AG, Lemaire SD (2018) Birth of a Photosynthetic Chassis: A MoClo Toolkit Enabling Synthetic Biology in the Microalga Chlamydomonas reinhardtii. ACS Synth. Biol. 7, 9, 2074-2086. Supp Tables and Figures

Maes A, Martinez X, Druart K, Laurent B, Guégan S, Marchand CH, Lemaire SD, Baaden M (2018) MinOmics, an Integrative and Immersive Tool for Multi-Omics Analysis. J. Integr Bioinform. 15(2).

Zhan Y, Marchand CH, Maes A, Mauries A, Sun Y, Dhaliwal JS, Uniacke J, Arragain S, Jiang H, Gold ND, Martin VJJ, Lemaire SD, Zerges W (2018). Pyrenoid functions revealed by proteomics in Chlamydomonas reinhardtii. PLoS One. 13(2):e0185039. Supp

Dautant A, Henri J, Wales TE, Meyer P, Engen JR, Georgescauld F. Remodeling of the binding site of nucleoside diphosphate kinase revealed by X-Ray structure and H/D exchange. Biochemistry. 2019 Feb 20.

Henri J, Chagot ME, Bourguet M, Abel Y, Terral G, Maurizy C, Aigueperse C, Georgescauld F, Vandermoere F, Saint-Fort R, Behm-Ansmant I, Charpentier B, Pradet-Balade B, Verheggen C, Bertrand E, Meyer P#, Cianférani S#, Manival X#, Quinternet M#. Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure. 2018 Sep 4;26(9):1196-1209.

Coutelier H*, Xu Z*#, Morisse MC,  Lhuillier-Akakpo M, Pelet S, Charvin G, Dubrana K and TeixeiraMT#. (2018). Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability. Genes & Dev. 32:1–15. [Supp]


Sevaille L, Gavara L, Bebrone C, De Luca F, Nauton L, Achard M, Mercuri P, Tanfoni S, Borgianni L, Guyon C, Lonjon P, Turan-Zitouni G, Dzieciolowski J, Becker K, Benard L, Condon C, Maillard L, Martinez J, Frere JM, Dideberg O, Galleni M, Docquier JD, Hernandez JF (2017) 1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-beta-lactamases. ChemMedChem 12: 972-985.

De Vecchis D, Cavellini L, Baaden M, Hénin J, Cohen MM and Taly A. A membrane-inserted structural model of the yeast mitofusin Fzo1. SCIentIfIC REPORTS, 7: 10217, doi:10.1038/s41598-017-10687-2

Cavellini L, Meurisse J, Findinier J, Erpapazoglou Z, Belgareh-Touzé N, Weissman AM and Cohen MM. An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion. Nature Communications 8, 15832. 2017. doi:10.1038/ncomms15832

Gold VA, Brandt T, Cavellini L, Cohen MM, Ieva R, van der Laan M. Analysis of Mitochondrial Membrane Protein Complexes by Electron Cryo-tomography. Methods Mol Biol. 2017;1567:315-336. doi: 10.1007/978-1-4939-6824-4_19.

Belgareh-Touzé N, Cavellini L, Cohen MM. Ubiquitination of ERMES components by the E3 ligase Rsp5 is involved in mitophagy. Autophagy. 2017 Jan 2;13(1):114-132. doi: 10.1080/15548627.2016.1252889.

Gergondey R, Garcia C, Marchand CH, Lemaire SD, Camadro JM, Auchère F (2017) Modulation of the specific glutathionylation of mitochondrial proteins in the yeast Saccharomyces cerevisiae under basal and stress conditions. Biochem J 474: 1175-1193

Pasquini M, Fermani S, Tedescoa D, Sciabolini C, Crozet P, Naldi M, Henri J, Vothknechte U, Bertuccia C, Lemaire SD, Zaffagnini M, Francia F (2017) Structural basis for the magnesium-dependent activation of transketolase from Chlamydomonas reinhardtii. Biochim Biophys Acta – General Subjects. 1861:2132-2145

Pérez-Pérez ME, Mauriès A, Maes A, Tourasse NJ, Hamon M, Lemaire SD, Marchand CH (2017) The deep thioredoxome in Chlamydomonas reinhardtii: new insights into redox regulation. Mol Plant 10: 1107-1125.

Dautant A, Meyer P, Georgescauld F. Hydrogen/Deuterium Exchange Mass Spectrometry Reveals Mechanistic Details of Activation of Nucleoside Diphosphate Kinases by Oligomerization. Biochemistry. 2017 Jun 13;56(23):2886-2896. doi: 10.1021/acs.biochem.7b00282.

Graf M, Bonetti D, Lockhart A, Serhal K, Kellner V, Maicher A, Jolivet P, Teixeira MT and Luke B. (2017). Telomere length determines TERRA and R-loop regulation through the cell cycle. Cell. Volume 170, Issue 1, p72–85.e14, 29 June 2017


Brandt T, Cavellini L, Kühlbrandt W, Cohen MM. A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro. Elife. 2016 Jun 2;5. pii: e14618. doi: 10.7554/eLife.14618.

Pérez-Pérez ME, Lemaire SD, Crespo JL (2016). Control of autophagy in Chlamydomonas is mediated through redox dependent inactivation of the ATG4 protease. Plant Physiol. 172: 2219-2234.

Zaffagnini M, De Mia M, Morisse S, Di Giacinto N, Marchand CH, Maes A, Lemaire SD, Trost P (2016) Protein S-nitrosylation in photosynthetic organisms: A comprehensive overview with future perspectives. Biochim Biophys Acta. 1864: 952-966.

Berger H, de Mia M, Morisse S, Marchand C, Lemaire SD, Wobbe L, Kruse O (2016) A light switch based on protein S-nitrosylation fine-tunes photosynthetic light-harvesting in the microalga Chlamydomonas reinhardtii. Plant Physiol. 171: 821-832.

Eugène S, Bourgeron T, Xu Z. (2016). Effects of initial telomere length distribution on senescence onset and heterogeneity. J Theor Biol.


Sinturel, F., Navickas, A., Wery, M., Descrimes, M., Morillon, A., Torchet, C. and Benard, L. (2015). Cytoplasmic control of sense-antisense messenger RNA pairs.  Cell Reports. Vol.12, Issue 11, Pages 1853-1864.

Blaby IK, Blaby-Haas CE, Pérez-Pérez ME, Schmollinger S, Fitz-Gibbon S, Lemaire SD, Merchant SS (2015) Genome-wide analysis on Chlamydomonas reinhardtii reveals the impact of hydrogen peroxide on protein stress responses and overlap with other stress transcriptomes. Plant J. 84(5):974-88.

Chardonnet S, Sakr S, Cassier-Chauvat C, Le Maréchal P, Chauvat F, Lemaire SD, Decottignies P (2015) First proteomic study of S-glutathionylation in cyanobacteria. J. Proteome Res. 14: 59-71. [Sup Data]

Bourgeron, T., Xu, Z.§* , Doumic, M. §, and Teixeira, M.T. (2015). The asymmetry of telomere replication contributes to replicative senescence heterogeneity. Sci Rep 5, 15326. [Supp1 , Supp2]

Xu, Z., Fallet, E., Paoletti, C., Fehrmann, S., Charvin, G., and Teixeira, M.T. § (2015). Two routes to senescence revealed by real-time analysis of telomerase-negative single lineages. Nat Commun 6, 7680. [Sup Data]


Mota, S., Vieira, N., Barbosa, S., Delaveau, T., Torchet, C., Le Saux, A., Garcia, M., Pereira, A., Lemoine, S., Coulpier, F., Darzacq, X., Benard, L., Casal, M., Devaux, F. and Paiva, S. (2014). Role of the DHH1 Gene in the Regulation of Monocarboxylic Acids Transporters Expression in Saccharomyces cerevisiae. PLoS One. 2014 Nov 3;9(11).

Delan-Forino C, Deforges J, Benard L, Sargueil B, Maurel MC, Torchet C. (2014) Structural Analyses of Avocado sunblotch viroid Reveal Differences in the Folding of Plus and Minus RNA Strands. Viruses. Jan 29;6(2):489-506. doi: 10.3390/v6020489.

Senissar M, Le Saux A, Belgareh-Touzé N, Adam C, Banroques J, Tanner NK.The DEAD-box helicase Ded1 from yeast is an mRNP cap-associated protein that shuttles between the cytoplasm and nucleus. Nucleic Acids Res. 2014;42(15):10005-22. doi: 10.1093/nar/gku584. Epub 2014 Jul 10.

Livnat-Levanon N., Kevei E., Kleifeld O., Krutauz D., Segref A., Rinaldi T., Erpapazoglou Z., Cohen M., Reis N., Hoppe T. and Glickman MH. (2014) Reversible 26S Proteasome Disassembly upon Mitochondrial Stress. Cell Reports, Cell Rep. 2014 Jun 12;7(5):1371-80. doi: 10.1016/j.celrep.2014.04.030. Epub 2014 May 22.

Zaffagnini M, Michelet L, Sciabolini C, Di Giacinto N, Morisse S, Marchand CH, Trost P, Fermani S, Lemaire SD (2014) High resolution crystal structure and redox properties of chloroplastic triosephosphate isomerase from Chlamydomonas reinhardtii. Mol Plant. 7(1): 101-120.

Morisse S, Zaffagnini M, Gao XH, Lemaire SD, Marchand CH (2014) Insight into protein S-nitrosylation in Chlamydomonas reinhardtii. Antioxid Redox Signal. 21(9):1271-84.  [Sup Data]

Veyel D, Sommer F, Muranaka LS, Rütgers M, Lemaire SD, Schroda M (2014) In vitro characterization of bacterial and chloroplast Hsp70 systems reveals an evolutionary optimization of the co-chaperones for their Hsp70 partner. Biochem J. 460(1):13-24.

de Paepe R, Lemaire SD, Danon A (2014) Cardiolipin at the heart of stress response across kingdoms. Plant Signal Behav. 9(9):e29228.

Pérez-Pérez ME, Zaffagnini M, Marchand CH, Crespo JL, Lemaire SD (2014) The yeast autophagy protease Atg4 is regulated by thioredoxin. Autophagy 10(11), 1953-64

Pérez-Martin M, Pérez-Pérez ME, Lemaire SD, Crespo JL (2014) Oxidative stress contributes to autophagy induction in response to endoplasmic reticulum stress in Chlamydomonas. Plant Physiol. 166(2):997-1008

Morisse S, Michelet L, Bedhomme M, Marchand CH, Calvaresi M, Trost P, Fermani S, Zaffagnini M, Lemaire SD (2014). Thioredoxin-dependent Redox Regulation of Chloroplastic Phosphoglycerate Kinase from Chlamydomonas reinhardtii. J Biol Chem. 289: 30012-24 

Soudet, J., Jolivet, P., and Teixeira, M.T. § (2014). Elucidation of the DNA end-replication problem in Saccharomyces cerevisiae. Mol Cell 53, 954-964.

Fallet, E., Jolivet, P., Soudet, J., Lisby, M., Gilson, E., and Teixeira, M.T. § (2014). Length-dependent processing of telomeres in the absence of telomerase. Nucleic Acids Res 42, 3648-3665.


Michelet L, Roach T, Fischer BB, Bedhomme M, Lemaire SD, Krieger-Liszkay A (2013) Down-regulation of catalase activity allows transient accumulation of a hydrogen peroxide signal in Chlamydomonas reinhardtii. Plant Cell Environ. 36(6):1204-1213.  [sup data]

Zaffagnini M, Morisse S, Bedhomme M, Marchand CH, Festa M, Rouhier N, Lemaire SD*, Trost P* (*: corresponding authors) (2013) Mechanisms of nitrosylation and denitrosylation of cytoplasmic glyceraldehyde-3-phosphate dehydrogenase from Arabidopsis thaliana. J Biol Chem 288(31):22777-22789.

Marteyn B, Sakr S, Farci S, Bedhomme M, Chardonnet S, Decottignies P, Lemaire SD, Cassier-Chauvat C, Chauvat F (2013) The Synechocystis PCC6803 MerA-like enzyme operates in the reduction of both mercury and uranium, under the control of the glutaredoxin 1 enzyme. J Bacteriol. 195(18):4138-4145.

Pineau B, Bourge M, Marion J, Mauve C, Gilard F, Maneta-Peyret L, Moreau P, Satiat-Jeunemaître B, Brown SC, De Paepe R, Danon A (2013) The importance of cardiolipin synthase for mitochondrial ultrastructure, respiratory function, plant development, and stress responses in Arabidopsis. Plant Cell. 25(10):4195-4208.

Zaffagnini M, Fermani S, Costa A, Lemaire SD, Trost P (2013) Plant cytoplasmic GAPDH: redox post-translational modifications and moonlighting properties. Front Plant Sci. 4:450.

Michelet L, Zaffagnini M, Morisse S, Sparla F, Pérez-Pérez ME, Francia F, Danon A, Marchand CH, Fermani S, Trost P, Lemaire SD (2013) Redox regulation of the Calvin-Benson cycle: something old, something new. Front. Plant Sci. 4:470.

Xu Z., Dao Duc K., Holcman D., and Teixeira M.T. (corr), (2013) The Length of the Shortest Telomere as the Major. Determinant of the Onset of Replicative Senescence. Genetics, Vol. 194, 847–857


Sinturel,  F.,  Bréchemier-Baey, D., Kiledjian, M., Condon C. and  L., Bénard, (2012) Activation of 5′-3′ exoribonuclease Xrn1 by co-factor Dcs1 is essential for mitochondrial function in yeast. Proc. Natl. Acad. Sci USA 109(21):8264-9.

Bedhomme M, Adamo M, Marchand CH, Couturier J, Rouhier N, Lemaire SD, Zaffagnini M, Trost P (2012) Glutathionylation of cytosolic glyceraldehyde-3-phosphate dehydrogenase from the model plant Arabidopsis thaliana is reversed by both glutaredoxins and thioredoxins in vitro. Biochem J. 445:337-347. [supplementary data]

Pérez-Pérez ME, Lemaire SD, Crespo JL (2012) Reactive oxygen species and autophagy in plants and algae. Plant Physiol. 160:156-164. 

Zaffagnini M, Bedhomme M, Lemaire SD, Trost P (2012) The emerging roles of protein glutathionylation in chloroplasts. Plant Sci. 185-186:86-96.

Marchand CH, Salmeron C, Bou Raad R, Méniche X, Chami M, Masi M, Blanot D, Daffé M, Tropis M, Huc E, Le Maréchal P, Decottignies P, Bayan N. (2012) Biochemical disclosure of the mycolate outer membrane of Corynebacterium glutamicum. J Bacteriol. 194(3):587-97.

Zaffagnini M, Bedhomme M, Marchand CH, Couturier J, Gao XH, Rouhier N, Trost P, Lemaire SD (2012) Glutaredoxin S12: unique properties for redox signaling. Antioxid Redox Signal 16: 17-32.

Zaffagnini M, Bedhomme M, Marchand CH, Morisse S, Trost P, Lemaire SD (2012) Redox Regulation in Photosynthetic Organisms: Focus on Glutathionylation. Antioxid Redox Signal. 16: 567-586.

Zaffagnini M, Bedhomme M, Groni H, Marchand CH, Puppo C, Gontero C, Cassier-Chauvat C, Decottignies P, Lemaire SD (2012) Glutathionylation in the photosynthetic model organism Chlamydomonas reinhardtii: a proteomic survey. Mol. Cell Proteomics. 11(2):M111.014142.  Figure supplémentaire S1