Publications

2018

Dautant A, Henri J, Wales TE, Meyer P, Engen JR, Georgescauld F. Remodeling of the binding site of nucleoside diphosphate kinase revealed by X-Ray structure and H/D exchange. Biochemistry. 2019 Feb 20. doi: 10.1021/acs.biochem.8b01308.

Henri J, Chagot ME, Bourguet M, Abel Y, Terral G, Maurizy C, Aigueperse C, Georgescauld F, Vandermoere F, Saint-Fort R, Behm-Ansmant I, Charpentier B, Pradet-Balade B, Verheggen C, Bertrand E, Meyer P#, Cianférani S#, Manival X#, Quinternet M#. Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure. 2018 Sep 4;26(9):1196-1209. doi: 10.1016/j.str.2018.06.002.

# correponding authors

2017

Dautant A, Meyer P, Georgescauld F.Hydrogen/Deuterium Exchange Mass Spectrometry Reveals Mechanistic Details of Activation of Nucleoside Diphosphate Kinases by Oligomerization. Biochemistry. 2017 Jun 13;56(23):2886-2896. doi: 10.1021/acs.biochem.7b00282.

2015

Quinternet M, Rothé B, Barbier M, Bobo C, Saliou JM, Jacquemin C, Back R, Chagot ME, Cianférani S, Meyer P, Branlant C, Charpentier B, Manival X. Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly. J Mol Biol. 2015 Aug 28;427(17):2816-39. doi: 10.1016/j.jmb.2015.07.012.

2014

Benbahouche NE, Iliopoulos I, Török I, Marhold J, Henri J, Kajava AV, Farkas R, Kempf T, Schnölzer M, Meyer P, Kiss I, Bertrand E, Mechler BM, Pradet-Balade B. Drosophila Spag is the homolog of RNA Polymerase II Associated Protein 3 (RPAP3), and recruits the Heat Shock Proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries. J Biol Chem. 2014 Jan 6.

2013

Back R, Dominguez C, Rothé B, Bobo C, Beaufils C, Moréra S, Meyer P, Charpentier B, Branlant C, Allain FH, Manival X (2013) High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex. Structure. S0969-2126(13)00296-7

2012

Gaude H, Aznar N, Delay A, Bres A, Buchet-Poyau K, Caillat C, Vigouroux A, Rogon C, Woods A, Vanacker JM, Höhfeld J, Perret C, Meyer P, Billaud M, Forcet C (2012) Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1. Oncogene. 31, 1582-91.

2011

Topalis D, Pradère U, Roy V, Caillat C, Azzouzi A, Broggi J, Snoeck R, Andrei G, Lin J, Eriksson S, Alexandre JA, El-Amri C, Deville-Bonne D, Meyer P, Balzarini J, Agrofoglio LA (2011) Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates. J Med Chem. 54, 222-32.

2010

Eckert K, Saliou JM, Monlezun L, Vigouroux A, Atmane N, Caillat C, Quevillon-Chéruel S, Madiona K, Nicaise M, Lazereg S, Van Dorsselaer A, Sanglier-Cianférani S, Meyer P*, Moréra S* (2010) The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity. J Biol Chem. 285,31304-12. *corresponding authors

2008

Caillat C, Topalis D, AgrofoglioLA, PochetS, BalzariniIJ, Deville-BonneD, Meyer P (2008) The crystal structure of poxvirus thymidylate kinase shows an unexpected dimerization with implications for antiviral therapy. Proc Natl Acad Sci USA. 105, 16900-5.

Olivares-Illana V, Meyer P, Gueguen-Chaignon P, Soulat D, Mijakovic I, Deutscher J, Cozzone AJ, Morera S, Grangeasse C, Nessler S (2008) Structural Basis for the Regulation Mechanism of the Tyrosine Kinase CapB from S. aureus., PLoS Biol. 6, e143. doi:10.1371.

2006

Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper PW, Prodromou C, Pearl LH (2006) Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature. 440, 1013-17.

2004

Meyer P, Prodromou C., Liao C, Hu B, Roe SM, Vaughan C K, Vlasic I, PanaretouB, Piper PW & Pearl LH (2004) Structural basis for the recruitement of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO J. 23, 511-519.

Roe SM, Ali MUM, Meyer P, Vaughan CK, PanaretouB, Piper PW, Prodromou C, & Pearl LH (2004) The mechanism of Hsp90 regulation by the protein kinase-specific co-chaperone p50cdc37. Cell. 116, 87-98.

2003

Meyer P, Prodromou C, Hu B, Vaughan C, Roe SM, PanaretouB, Piper PW & Pearl LH (2003) Crystal structure and functional analysis of the middle segment of Hsp90: Implications for ATP hydrolysis and client protein and co-chaperone interactions. Mol Cell. 11, 647-658.

2002

Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH & Prodromou C (2002) Activation of the ATPase activity of Hsp90 by Aha1, a novel stress-regulated co-chaperone. Mol Cell. 10,1307-1318

Siligardi G, Panaretou B, Meyer P, Singh S, Woolfson DN, Piper PW, Pearl LH, Prodromou C (2002) Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. J Biol Chem. 277, 20151-9.

2000

Meyer P, Schneider B, Sarfati S, Deville-Bonne D, Guerreiro C, Boretto J, Janin J, Véron M & Canard B (2000) Structural basis for activation of -boranophosphosphate nucleotide analogues targeting drug resistant reverse transcriptase. EMBO J. 19, 3520-3529.