Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
Laboratory of Molecular and Cellular Biology of Eukaryotes
The DNA Damage Response (DDR) is a complex signaling cascade elicited in the cell by damaged DNA, orchestrated by apical protein kinases, assisted by sensors and effectors. The two master kinases upstream of the DDR, ATR and ATM, are thought to mainly respond to single-stranded DNA and double strand breaks, respectively.
Re-appraising the role of R-loops in transcription-driven genome instability Dr. Vincent Vanoosthuyse LBMC, ENS-Lyon, France invité par Teresa Teixeira Lundi 24 Novembre 2025, à 10h30 à la Salle de Conférences de l’IBPC
L’accumulation de protéines altérées constitue un défi majeur pour les cellules, qui ont développé des systèmes de contrôle afin d’en limiter les effets délétères. Les cellules disposent de mécanismes pour résoudre les blocages ribosomiques survenant lors d’une traduction défectueuse.
Les équipes Biologie des Télomères et Régulation Fonctionnelle et Surveillance de l’ARN ont participé au congrès Yeast 2025 à Sorbonne Université ROS increase precedes replicative senescence in Saccharomyces cerevisiae presented by Dr Aurelia Barascu Telomeres, replicative senescence and genomic instability: Read more
Mitochondria assemble in a dynamic tubular network. Their morphology is governed by mitochondrial fusion and fission, which regulate most mitochondrial functions including oxidative phosphorylation.
Previous studies using ubiquitin traps combined with mass spectrometry revealed that in Bortezomib (BTZ) resistant Mantle Cell Lymphoma (MCL) cells, a selective autophagy mechanism, known as proteaphagy, was a main mechanism eliminating the proteasome and reducing the sensitivity to this treatment
Telomere shortening ultimately causes replicative senescence.
Northern blot, or RNA blot, is a widely used technique in molecular biology to detect and semi-quantify specific RNAs. The advantage of this method is its ability to simultaneously estimate the sizes and quantities of degraded or processed RNA products.
Chromosome-end protection is crucial for genome stability, with telomere loops (t-loops) thought to play an important protective role. In most cell types, t-loop stabilization relies on the shelterin protein TRF2, while the regulatory pathways in pluripotent cells remain undefined.
La Collection de minéraux de Sorbonne Université regroupe l’une des plus anciennes collections de minéraux de France.