Jan
27
Nouvelle publication de l’équipe Biologie des télomères
Telomere shortening ultimately causes replicative senescence.
Auteur/autrice : LBMCE
Jan
03
Nouvelle publication de l’équipe Régulation Fonctionnelle et Surveillance de l’ARN
Northern blot, or RNA blot, is a widely used technique in molecular biology to detect and semi-quantify specific RNAs. The advantage of this method is its ability to simultaneously estimate the sizes and quantities of degraded or processed RNA products.
Déc
09
Seminaire de Jérôme DEJARDIN
Chromosome-end protection is crucial for genome stability, with telomere loops (t-loops) thought to play an important protective role. In most cell types, t-loop stabilization relies on the shelterin protein TRF2, while the regulatory pathways in pluripotent cells remain undefined.
Nov
08
Visite de la Collection de minéraux de Sorbonne Université
La Collection de minéraux de Sorbonne Université regroupe l’une des plus anciennes collections de minéraux de France.
Oct
11
Prisca BERARDI – Soutenance de thèse
« Réponses Moléculaire et Cellulaire au télomère les plus court chez Saccharomyces cerevisiae » dirigée par Dr Teresa Teixeira
La soutenance se tiendra le vendredi 11 Octobre 2024 à 14h, dans la Bibliothèque Edmond de Rothschild de l’Institut de Biologie Physico-Chimique (IBPC) au 13 rue Pierre et Marie Curie 75005, Paris
Oct
10
Seminaire de Eros Lazzerini Denchi
Telomeres, the natural ends of chromosomes, resemble double-strand breaks (DSBs) and require protection by the shelterin complex to prevent aberrant activation of the DNA damage response (DDR) in somatic cells.
Sep
19
Nouvelle publication de l’équipe Dynamique Membranaire et Modifications Post-Traductionnelles
Outer mitochondrial membrane fusion, a vital cellular process, is mediated by mitofusins. However, the underlying molecular mechanism remains elusive.
Sep
09
Séminaire du Prof. Dennis KAPPEI
Telomere maintenance is a universal hallmark of cancers to sustain the unlimited proliferative potential. In ~85% of cancers, telomere shortening is mitigated by reactivated telomerase expression while the other ~15% use a recombination-based mechanism, termed Alternative Lengthening of Telomeres (ALT)
Avr
29
Nouvelle publication de l’équipe Dynamique Membranaire et Modifications Post-Traductionnelles
Mitofusins are large GTPases that trigger fusion of mitochondrial outer membranes. Similarly to the human mitofusin Mfn2, which also tethers mitochondria to the endoplasmic reticulum (ER), the yeast mitofusin Fzo1 stimulates contacts between Peroxisomes and Mitochondria when overexpressed.
Avr
15
Nouvelle publication de l’équipe Chaperons Moléculaires et Biogenèse des Assemblages Macromoléculaires
Identification of Cellular Protein Targets of a Half-Sandwich Iridium (III) Complex Reveals Its Dual Mechanism of Action via Both Electrophilic and Oxidative Stresses Robin Ramos , Anthi Karaiskou, Candice Botuha, Sadek Amhaz, Michaël Trichet, Florent Dingli, Jérémy Forté, France Lam, Read more