Publications

2025

Singh, M.K., Cavellini, L., Morcillo-Parra, M.A., Kunz C., Lelek M., Bomme P., Barascu A., Alsayyah C., Teixeira M.T., Belgareh-Touzé N., Mallet A., Dietrich L., Zimmer C. & Cohen M.M. A constricted mitochondrial morphology formed during respiration. Nat Commun 16, 5314 (2025). https://doi.org/10.1038/s41467-025-60658-9

2024

Raphaëlle Versini, Marc Baaden, Laetitia Cavellini, Mickaël M. Cohen, Antoine Taly, Patrick F.J. Fuchs. Lys716 in the transmembrane domain of yeast mitofusin Fzo1 modulates anchoring and fusion. 2024, Structure 32, 1–16

Hilal Yeter-Alat, Naïma Belgareh-Touzé, Agnès Le Saux, Emmeline Huvelle, Molka Mokdadi, Josette Banroquesand N. Kyle Tanner. The RNA Helicase Ded1 from Yeast Is Associated with the Signal Recognition Particle and Is Regulated by SRP21. Molecules 2024, 29(12), 2944

Alsayyah C, Singh MK, Morcillo-Parra MA, Cavellini L, Shai N, Schmitt C, Schuldiner M, Zalckvar E, Mallet A, Belgareh-Touzé N, Zimmer C, Cohen MM. Mitofusin-mediated contacts between mitochondria and peroxisomes regulate mitochondrial fusion. PLoS Biol. 2024 Apr 26;22(4):e3002602. doi: 10.1371/journal.pbio.3002602

2023

Raphaëlle Versini, Marc Baaden, Mickael M Cohen, Laetitia Cavellini, Antoine Taly, Patrick F J Fuchs. Lys716 in the transmembrane domain of yeast mitofusin Fzo1 modulates anchoring and fusion. bioRxiv 2023.09.22.559002; doi: https://doi.org/10.1101/2023.09.22.559002

Vlieghe A, Niort K, Fumat H, Guigner J-M, Cohen MM, Tareste D. Role of Lipids and Divalent Cations in Membrane Fusion Mediated by the Heptad Repeat Domain 1 of Mitofusin. Biomolecules. 2023; 13(9):1341. https://doi.org/10.3390/biom13091341

Yeter-Alat H, Belgareh-Touzé N, Huvelle E, Banroques J and Tanner K N. The DEAD-Box RNA Helicase Ded1 Is Associated with Translating Ribosomes. 2023. Genes, 14(8), 1566

Grégoire Quinet, Pierre Génin, Naima Belgareh-Touzé, Oznur Ozturk, Robert Weil, Mickael M. Cohen, Renaud Legouis & Manuel S. Rodriguez. Analysis of ATG8 Family Members Using LC3-Interacting Regions (LIR)-Based Molecular Traps. 2023. The Ubiquitin Code. Methods in Molecular Biology, vol 2602

2022

Ouyang W, Bai J, Singh MK, Leterrier C, Barthelemy P, Barnett SFH, Klein T, Sauer M, Kanchanawong P, Bourg N, Cohen MM, Lelandais B, Zimmer C. ShareLoc – an open platform for sharing localization microscopy data. Nat Methods. 2022 Oct 21. doi: 10.1038/s41592-022-01659-0.

Ozeir M, Cohen MM. From dynamin related proteins structures and oligomers to membrane fusion mediated by Mitofusins. Biochim Biophys Acta Bioenerg. 2022 Aug 31:148913. doi: 10.1016/j.bbabio.2022.148913.

Quinet G, Génin P, Ozturk O, Belgareh-Touzé N, Courtot L, Legouis R, Weil R, Cohen MM, Rodriguez MS. Exploring selective autophagy events in multiple biologic models using LC3-interacting regions (LIR)-based molecular traps. Sci Rep. 2022 May 10;12(1):7652. doi: 10.1038/s41598-022-11417-z. PMID: 35538106

2021

Klionsky DJ, ……Belgareh-Touzé N, ………Cohen MM, ………Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751

2020

Alsayyah C, Ozturk O, Cavellini L, Belgareh-Touzé N, Cohen MM. The regulation of mitochondrial homeostasis by the Ubiquitin Proteasome System. Biochim Biophys Acta Bioenerg. 2020 Aug 27:148302. doi: 10.1016/j.bbabio.2020.148302.

2019

Brandner A, De Vecchis D, Baaden M, Cohen MM, Taly A. Structural dataset from microsecond-long simulations of yeast mitofusin Fzo1 in the context of membrane docking. Data in Brief 26, 104460

De Vecchis D, Brandner A, Baaden M, Cohen MM, Taly A. A Molecular Perspective on Mitochondrial Membrane Fusion: From the Key Players to Oligomerization and Tethering of Mitofusin. The Journal of membrane biology, 1-14

Brandner A, De Vecchis D, Baaden M, Cohen MM*, Taly A^*. Physics-based oligomeric models of the yeast mitofusin Fzo1 at the molecular scale in the context of membrane docking. Mitochondrion. 2019 Jul 12. pii: S1567-7249(19)30051-0. doi: 10.1016/j.mito.2019.06.010. 

*Corresponding authors

Findinier J, Delevoye C, Cohen MM. The dynamin-like protein Fzl promotes thylakoid fusion and resistance to light stress in Chlamydomonas reinhardtii. PLoS Genet. 2019 Mar 15;15(3):e1008047. doi: 10.1371/journal.pgen.1008047. [Epub ahead of print]

2018

Cohen MM.* and Tareste D.* Recent insights into the structure and function of Mitofusins in mitochondrial fusion. (2018) . F1000 Research. 7 (F1000 Faculty Rev):1983.

*Corresponding authors

Shai N, Yifrach E, van Roermund CWT, Cohen N, Bibi C, IJlst L, Cavellini L, Meurisse J, Schuster R, Zada L, Mari MC, Reggiori FM, Hughes AL, Escobar-Henriques M, Cohen MM, Waterham HR, Wanders RJA, Schuldiner M, Zalckvar E. Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact. Nat Commun. 2018 May 2;9(1):1761. doi: 10.1038/s41467-018-03957-8.

2017

De Vecchis D, Cavellini L, Baaden M, Hénin J, Cohen MM and Taly A. A membrane-inserted structural model of the yeast mitofusin Fzo1. SCIentIfIC REPORTS, 7: 10217, doi:10.1038/s41598-017-10687-2

Cavellini L, Meurisse J, Findinier J, Erpapazoglou Z, Belgareh-Touzé N, Weissman AM and Cohen MM. An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion. Nature Communications 8, 15832. 2017. doi:10.1038/ncomms15832

Gold VA, Brandt T, Cavellini L, Cohen MM, Ieva R, van der Laan M. Analysis of Mitochondrial Membrane Protein Complexes by Electron Cryo-tomography. Methods Mol Biol. 2017;1567:315-336. doi: 10.1007/978-1-4939-6824-4_19.

Belgareh-Touzé N, Cavellini L, Cohen MM. Ubiquitination of ERMES components by the E3 ligase Rsp5 is involved in mitophagy. Autophagy. 2017 Jan 2;13(1):114-132. doi: 10.1080/15548627.2016.1252889.

2016

Brandt T, Cavellini L, Kühlbrandt W, Cohen MM. A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro. Elife. 2016 Jun 2;5. pii: e14618. doi: 10.7554/eLife.14618.

2014

Senissar M, Le Saux A, Belgareh-Touzé N, Adam C, Banroques J, Tanner NK.The DEAD-box helicase Ded1 from yeast is an mRNP cap-associated protein that shuttles between the cytoplasm and nucleus. Nucleic Acids Res. 2014;42(15):10005-22. doi: 10.1093/nar/gku584. Epub 2014 Jul 10.

Livnat-Levanon N., Kevei E., Kleifeld O., Krutauz D., Segref A., Rinaldi T., Erpapazoglou Z., Cohen M., Reis N., Hoppe T. and Glickman MH. (2014) Reversible 26S Proteasome Disassembly upon Mitochondrial Stress. Cell Reports, Cell Rep. 2014 Jun 12;7(5):1371-80. doi: 10.1016/j.celrep.2014.04.030. Epub 2014 May 22.

2011

Cohen MM., Amiott EA., Day AR., Leboucher GP., Pryce EN., Glickman MH., McCaffery JM., Shaw JM. and Weissman AM. (2011) Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci 124: 1403-1410

2010

Ossareh-Nazari B, Cohen M and Dargemont C. (2010) The Rsp5 ubiquitin ligase and the AAA-ATPase Cdc48 control the ubiquitin-mediated degradation of the COPII component Sec23. Exp Cell Res. 316(20):3351-7.

Ossareh-Nazari B., Bonizec M., Cohen M., Dokudovskaya S., Delalande F., Schaeffer C., Van Dorsselaer A. and Dargemont C. (2010) Cdc48 and Ufd3, novel partners of the ubiquitin protease Ubp3, are required for ribophagy. EMBO Reports. 11(7):548-54

2009

Amiott EA., Cohen MM., Saint-Georges Y., Weissman AM., and Shaw JM. (2009) A Mutation Associated with CMT2A Neuropathy Causes Defects in Fzo1 GTP Hydrolysis, Ubiquitylation, and Protein Turnover. Mol. Biol. Cell. 20(23):5026-35.

2008

Cohen MM., Leboucher GP., Levanon N., Glickman MH. and Weissman AM. (2008) Ubiquitin-Proteasome Dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol. Biol. Cell. 19(6):2457-64. (Selected for MBC InCytes June 2008)

2006

Chen B, Mariano J, Tsai YC, Chan AH, Cohen M, Weissman AM. (2006) The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger and E2-binding site. P.N.A.S. 103(2); 341-6.

2003

Cohen M., Stutz F., Belgareh N., Haguenauer-Tsapis R and Dargemont C. (2003) Ubp3p requires a co-factor, Bre5p, to specifically de-ubiquitinate the COPII protein, Sec23p. Nature Cell Biology. 5(7); 661-7.

Cohen M., Stutz F. and Dargemont C. (2003) Deubiquitination, a new player in Golgi to Endoplasmic Reticulum retrograde transport. J. Biol. Chem. 278(52); 51989-92.