Seminar from Gwenael Badis-Bréard

An NMD-type pathway linking the polyA tail and mRNA degradation

Gwenael Badis-Bréard, Institut Pasteur/CNRS UMR3525

The Nonsense-mediated mRNA decay (NMD) is the major surveillance pathway that degrades aberrant mRNAs with premature termination codons. We identified a population of deadenylated RNA molecules, distinct from NMD targets, that are specifically bound by the NMD core factor Upf1. How these RNA are generated and specifically bound by Upf1 is unknown. By analogy with the recruitment of Upf1 in NMD, we propose a mechanism leading to the recruitment of this helicase on non-canonical NMD targets.

Invited by Lionel Benard and Maude Guiller (UMR8261)

June 30th 11:30 at the IBPC Conference room