Category: News

Telomere shortening ultimately causes replicative senescence.

Outer mitochondrial membrane fusion, a vital cellular process, is mediated by mitofusins. However, the underlying molecular mechanism remains elusive.

Replicative senescence is triggered when telomeres reach critically short length and activate permanent DNA damage checkpoint-dependent cell cycle arrest.

Identification of Cellular Protein Targets of a Half-Sandwich Iridium (III) Complex Reveals Its Dual Mechanism of Action via Both Electrophilic and Oxidative Stresses Robin Ramos , Anthi Karaiskou, Candice Botuha, Sadek Amhaz, Michaël Trichet, Florent Dingli, Jérémy Forté, France Lam, Read more

Individual cell fate and population dynamics revealed by a mathematical model linking telomere length and replicative senescence A. Rat, M. Doumic, M. T. Teixeira and Z. Xu. Progressive shortening of telomeres ultimately causes replicative senescence and is linked with aging Read more

« Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation » Bechara Zeinoun, Maria Teresa Teixeira and Aurélia Barascu Replicative senescence is triggered when telomeres reach critically short length and activate permanent DNA damage checkpoint-dependent cell cycle arrest. Read more

“Replicative senescence-associated oxidative stress and Hog1 activation in telomerase negative Saccharomyces cerevisiae cells” directed by Dr Teresa Teixeira and Dr Aurélia Barascu.

The defense will be held at the Institute of Physico-Chemical Biology (IBPC) on December 8 at 2 p.m., at 13 rue Pierre et Marie Curie at the Edmond de Rothschild library.

On the occasion of the International Day for the Elimination of Violence against Women, the Laboratory of Molecular and Cellular Biology of Eukaryotes and Sorbonne University are joining forces with UN Women’s “Orange Day” on 22 to November 29, 2023. Read more

Lys716 in the transmembrane domain of yeast mitofusin Fzo1 modulates anchoring and fusion Raphaelle Versini, Marc Baaden, Laetitia Cavellini, Mickael M. Cohen, Antoine Taly, and Patrick F.J. Fuchs Outer mitochondrial membrane (OMM) fusion is an important process for the cell Read more

Role of Lipids and Divalent Cations in Membrane Fusion Mediated by the Heptad Repeat Domain 1 of Mitofusin Vlieghe A, Niort K, Fumat H, Guigner J-M, Cohen MM, Tareste D. Biomolecules. 2023; 13(9):1341. https://doi.org/10.3390/biom13091341 Mitochondria are highly dynamic organelles that Read more