Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
Laboratory of Molecular and Cellular Biology of Eukaryotes
Previous studies using ubiquitin traps combined with mass spectrometry revealed that in Bortezomib (BTZ) resistant Mantle Cell Lymphoma (MCL) cells, a selective autophagy mechanism, known as proteaphagy, was a main mechanism eliminating the proteasome and reducing the sensitivity to this treatment.
Telomere shortening ultimately causes replicative senescence.
TELS1 reveals a minor contribution for telomere loops in chromosome end-protection Dr Jérôme Dejardin invité par Maria Teresa Teixeira Lundi 9 Décembre 2024 à 10:30 à l’IBPC – Salle de Conférences 3è étage Chromosome-end protection is crucial for genome stability, Read more
“Molecular and Cellular Responses to the Shortest Telomere in Saccharomyces cerevisiae”
directed by Dr Teresa Teixeira.
The defense will take place on Friday, October 11, 2024, at 2:00 PM, in the Edmond de Rothschild Library at the Institut de Biologie Physico-Chimique (IBPC), located at 13 rue Pierre et Marie Curie, 75005 Paris.
Outer mitochondrial membrane fusion, a vital cellular process, is mediated by mitofusins. However, the underlying molecular mechanism remains elusive.
Telomere maintenance is a universal hallmark of cancers to sustain the unlimited proliferative potential. In ~85% of cancers, telomere shortening is mitigated by reactivated telomerase expression while the other ~15% use a recombination-based mechanism, termed Alternative Lengthening of Telomeres (ALT).
Replicative senescence is triggered when telomeres reach critically short length and activate permanent DNA damage checkpoint-dependent cell cycle arrest.
Identification of Cellular Protein Targets of a Half-Sandwich Iridium (III) Complex Reveals Its Dual Mechanism of Action via Both Electrophilic and Oxidative Stresses Robin Ramos , Anthi Karaiskou, Candice Botuha, Sadek Amhaz, Michaël Trichet, Florent Dingli, Jérémy Forté, France Lam, Read more
Individual cell fate and population dynamics revealed by a mathematical model linking telomere length and replicative senescence A. Rat, M. Doumic, M. T. Teixeira and Z. Xu. Progressive shortening of telomeres ultimately causes replicative senescence and is linked with aging Read more
« Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation » Bechara Zeinoun, Maria Teresa Teixeira and Aurélia Barascu Replicative senescence is triggered when telomeres reach critically short length and activate permanent DNA damage checkpoint-dependent cell cycle arrest. Read more