Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
Laboratory of Molecular and Cellular Biology of Eukaryotes
Accumulation of impaired proteins presents a critical challenge for cells, and control systems have evolved to minimize their detrimental effects. Cells have developed mechanisms to address ribosomal stalls caused by problematic translation.
The Telomere Biology and Functional Regulation and RNA Surveillance teams participated in the Yeast 2025 conference at Sorbonne University.
Mitochondria assemble in a dynamic tubular network. Their morphology is governed by mitochondrial fusion and fission, which regulate most mitochondrial functions including oxidative phosphorylation.
Previous studies using ubiquitin traps combined with mass spectrometry revealed that in Bortezomib (BTZ) resistant Mantle Cell Lymphoma (MCL) cells, a selective autophagy mechanism, known as proteaphagy, was a main mechanism eliminating the proteasome and reducing the sensitivity to this treatment.
Telomere shortening ultimately causes replicative senescence.
Northern blot, or RNA blot, is a widely used technique in molecular biology to detect and semi-quantify specific RNAs. The advantage of this method is its ability to simultaneously estimate the sizes and quantities of degraded or processed RNA products.