Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
Laboratory of Molecular and Cellular Biology of Eukaryotes
Outer mitochondrial membrane fusion, a vital cellular process, is mediated by mitofusins. However, the underlying molecular mechanism remains elusive.
Telomere maintenance is a universal hallmark of cancers to sustain the unlimited proliferative potential. In ~85% of cancers, telomere shortening is mitigated by reactivated telomerase expression while the other ~15% use a recombination-based mechanism, termed Alternative Lengthening of Telomeres (ALT).