Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
Laboratory of Molecular and Cellular Biology of Eukaryotes
“Molecular and Cellular Responses to the Shortest Telomere in Saccharomyces cerevisiae”
directed by Dr Teresa Teixeira.
The defense will take place on Friday, October 11, 2024, at 2:00 PM, in the Edmond de Rothschild Library at the Institut de Biologie Physico-Chimique (IBPC), located at 13 rue Pierre et Marie Curie, 75005 Paris.
Telomeres, the natural ends of chromosomes, resemble double-strand breaks (DSBs) and require protection by the shelterin complex to prevent aberrant activation of the DNA damage response (DDR) in somatic cells.
Outer mitochondrial membrane fusion, a vital cellular process, is mediated by mitofusins. However, the underlying molecular mechanism remains elusive.
Telomere maintenance is a universal hallmark of cancers to sustain the unlimited proliferative potential. In ~85% of cancers, telomere shortening is mitigated by reactivated telomerase expression while the other ~15% use a recombination-based mechanism, termed Alternative Lengthening of Telomeres (ALT).
Replicative senescence is triggered when telomeres reach critically short length and activate permanent DNA damage checkpoint-dependent cell cycle arrest.
Identification of Cellular Protein Targets of a Half-Sandwich Iridium (III) Complex Reveals Its Dual Mechanism of Action via Both Electrophilic and Oxidative Stresses Robin Ramos , Anthi Karaiskou, Candice Botuha, Sadek Amhaz, Michaël Trichet, Florent Dingli, Jérémy Forté, France Lam, Read more