Exploring the regulation and function of
telomeric non-coding RNA TERRA in budding yeast
Pascal CHARTRAND
Université de Montréal
Faculté de Médecine
Département de biochimie et de médecine moléculaire
invited by Bechara Zeinoun
Thursday 7 December 2023, at 14:00 pm at Conference room – IBPC (third floor)
Telomeres are transcribed in a strand specific manner, giving rise to a G-rich telomeric-repeat containing RNA (TERRA). The role of TERRA in telomere biology has been extensively studied in the context of replicative senescence, in the absence of telomerase, where TERRA forms RNA-DNA hybrids at telomeres and promotes recombination. Still, the role of TERRA
in telomerase-positive cells remains unknown. We previously showed that TERRA is expressed preferentially from short telomeres and interacts with telomerase, promoting the formation of telomerase clusters or T-Recs during telomeres elongation in S phase. In this talk, I will present our recent results on the role of cohesin in the regulation of TERRA expression from short telomeres. New mechanistic insights on the interaction between TERRA and telomerase will also be discussed.