Publications

Team
Members

2024

Ramos R, Karaiskou A, Botuha C, Amhaz S, Trichet M, Dingli F, Forté J, Lam F, Canette A, Chaumeton C, Salome M, Chenuel T, Bergonzi C, Meyer P, Bohic S, Loew D, Salmain M, Sobczak-Thépot J. Identification of Cellular Protein Targets of a Half-Sandwich Iridium(III) Complex Reveals Its Dual Mechanism of Action via Both Electrophilic and Oxidative Stresses.
J Med Chem. 2024 Apr 5. doi: 10.1021/acs.jmedchem.3c02000.

2018

Dautant A, Henri J, Wales TE, Meyer P, Engen JR, Georgescauld F. Remodeling of the binding site of nucleoside diphosphate kinase revealed by X-Ray structure and H/D exchange. Biochemistry. 2019 Feb 20. doi: 10.1021/acs.biochem.8b01308.

Henri J, Chagot ME, Bourguet M, Abel Y, Terral G, Maurizy C, Aigueperse C, Georgescauld F, Vandermoere F, Saint-Fort R, Behm-Ansmant I, Charpentier B, Pradet-Balade B, Verheggen C, Bertrand E, Meyer P#, Cianférani S#, Manival X#, Quinternet M#. Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex. Structure. 2018 Sep 4;26(9):1196-1209. doi: 10.1016/j.str.2018.06.002.

# correponding authors

2017

Dautant A, Meyer P, Georgescauld F. Hydrogen/Deuterium Exchange Mass Spectrometry Reveals Mechanistic Details of Activation of Nucleoside Diphosphate Kinases by Oligomerization. Biochemistry. 2017 Jun 13;56(23):2886-2896. doi: 10.1021/acs.biochem.7b00282.

2015

Quinternet M, Rothé B, Barbier M, Bobo C, Saliou JM, Jacquemin C, Back R, Chagot ME, Cianférani S, Meyer P, Branlant C, Charpentier B, Manival X. Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly. J Mol Biol. 2015 Aug 28;427(17):2816-39. doi: 10.1016/j.jmb.2015.07.012.

2014

Benbahouche NE, Iliopoulos I, Török I, Marhold J, Henri J, Kajava AV, Farkas R, Kempf T, Schnölzer M, Meyer P, Kiss I, Bertrand E, Mechler BM, Pradet-Balade B. Drosophila Spag is the homolog of RNA Polymerase II Associated Protein 3 (RPAP3), and recruits the Heat Shock Proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries. J Biol Chem. 2014 Jan 6.

2013

Back R, Dominguez C, Rothé B, Bobo C, Beaufils C, Moréra S, Meyer P, Charpentier B, Branlant C, Allain FH, Manival X (2013) High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex. Structure. S0969-2126(13)00296-7

2012

Gaude H, Aznar N, Delay A, Bres A, Buchet-Poyau K, Caillat C, Vigouroux A, Rogon C, Woods A, Vanacker JM, Höhfeld J, Perret C, Meyer P, Billaud M, Forcet C (2012) Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1. Oncogene. 31, 1582-91.

2011

Topalis D, Pradère U, Roy V, Caillat C, Azzouzi A, Broggi J, Snoeck R, Andrei G, Lin J, Eriksson S, Alexandre JA, El-Amri C, Deville-Bonne D, Meyer P, Balzarini J, Agrofoglio LA (2011) Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates. J Med Chem. 54, 222-32.

2010

Eckert K, Saliou JM, Monlezun L, Vigouroux A, Atmane N, Caillat C, Quevillon-Chéruel S, Madiona K, Nicaise M, Lazereg S, Van Dorsselaer A, Sanglier-Cianférani S, Meyer P*, Moréra S* (2010) The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity. J Biol Chem. 285,31304-12. *corresponding authors

2008

Caillat C, Topalis D, AgrofoglioLA, PochetS, BalzariniIJ, Deville-BonneD, Meyer P (2008) The crystal structure of poxvirus thymidylate kinase shows an unexpected dimerization with implications for antiviral therapy. Proc Natl Acad Sci USA. 105, 16900-5.

Olivares-Illana V, Meyer P, Gueguen-Chaignon P, Soulat D, Mijakovic I, Deutscher J, Cozzone AJ, Morera S, Grangeasse C, Nessler S (2008) Structural Basis for the Regulation Mechanism of the Tyrosine Kinase CapB from S. aureus., PLoS Biol. 6, e143. doi:10.1371.

2006

Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper PW, Prodromou C, Pearl LH (2006) Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature. 440, 1013-17.

2004

Meyer P, Prodromou C., Liao C, Hu B, Roe SM, Vaughan C K, Vlasic I, PanaretouB, Piper PW & Pearl LH (2004) Structural basis for the recruitement of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO J. 23, 511-519.

Roe SM, Ali MUM, Meyer P, Vaughan CK, PanaretouB, Piper PW, Prodromou C, & Pearl LH (2004) The mechanism of Hsp90 regulation by the protein kinase-specific co-chaperone p50cdc37. Cell. 116, 87-98.

2003

Meyer P, Prodromou C, Hu B, Vaughan C, Roe SM, PanaretouB, Piper PW & Pearl LH (2003) Crystal structure and functional analysis of the middle segment of Hsp90: Implications for ATP hydrolysis and client protein and co-chaperone interactions. Mol Cell. 11, 647-658.

2002

Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH & Prodromou C (2002) Activation of the ATPase activity of Hsp90 by Aha1, a novel stress-regulated co-chaperone. Mol Cell. 10,1307-1318

Siligardi G, Panaretou B, Meyer P, Singh S, Woolfson DN, Piper PW, Pearl LH, Prodromou C (2002) Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. J Biol Chem. 277, 20151-9.

2000

Meyer P, Schneider B, Sarfati S, Deville-Bonne D, Guerreiro C, Boretto J, Janin J, Véron M & Canard B (2000) Structural basis for activation of -boranophosphosphate nucleotide analogues targeting drug resistant reverse transcriptase. EMBO J. 19, 3520-3529.